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NAD+ and Its Potential of Boosting Exercise Performance

Sports participation and regular exercise have a huge positive impact on one’s health and well-being. From weekend warriors to elite athletes, individuals across the spectrum are constantly searching for strategies to enhance their performance and expedite recovery.

Nevertheless, even the most committed athletes occasionally reach a plateau where their progress in performance stops. While some resort to supplements and specific diets, an expanding body of research proposes that NAD+ might be the elusive element. Therefore, looking into cutting-edge treatments like NAD IV therapy NYC could give you an advantage.

Why NAD+ Might Benefit Athletic Performance?

Multiple studies have indicated that elevating NAD+ levels may positively impact athletic performance. A 2016 study published in Cell Metabolism discovered that Nicotinamide Riboside (NR) supplementation enhanced endurance capacity in mice. This improvement was ascribed to improved skeletal muscle fatty acid oxidation and increased mitochondrial biogenesis.

Similarly, a study published in Nature Communications 2020 found that Nicotinamide Mononucleotide (NMN) supplementation improved exercise performance in mice. This enhancement was linked to improved mitochondrial function and reduced oxidative stress within skeletal muscle. The researchers observed that NMN supplementation also increased muscle strength and endurance, particularly in older mice.

The NAD+ Boost

NAD+ Supports Cellular Energy Function

As a critical coenzyme, NAD+ plays an integral role in producing ATP, the key energy molecule utilized by cells. Maintaining optimal NAD+ levels may translate to improved energy outputs and physical stamina.

NAD+ Helps Relieve Oxidative Damage from Exercise

Animal research indicates NAD+ helps mitigate oxidative stress, a byproduct of strenuous activity contributing to muscle fatigue and delayed workout recovery. Sustaining healthy NAD+ levels could support quicker bounce-back post-exercise.

Emerging Evidence for Performance Benefits

Early lab mouse studies report that providing NAD+ precursors boosted endurance markers and lowered fatigue. In parallel, small human trials demonstrate that maintaining NAD+ levels correlates with positive changes in key athletic indicators like VO2 max and lactate threshold.

Athletes should also investigate any regulations on NAD+ supplements within their sport’s governing body.

Accelerates Post-Workout Recovery

Muscle fibers are strained during intense training sessions, leading to small tears and injury. The body then uses a lot of biological energy to repair damaged tissues by synthesizing new proteins. After strenuous exercise, muscles can quickly rebuild and regain their strength thanks to sufficient NAD+ levels, which optimize energy capacity and stimulate this repair process. A faster recovery time enables more frequent high-intensity workouts.

Shields Neural Pathways from Burnout

Excessive physical activity produces free radicals and oxidative chemicals that, if unchecked, can damage brain connections. NAD+ efficiently prevents fatigue by reducing inflammation and oxidative stress in the central nervous system pathways. This preserves rapid decision-making during competition, stabilizes reaction speed, and maintains accurate muscular synchronization.

Boosts Oxygen Delivery and Utilization

One vital aspect of NAD+ is supporting healthy mitochondrial populations within muscle tissue. The mitochondria serve as the energy factories of cells. An abundance of high-functioning mitochondria means more ATP production for powerful muscular contractions. It also enhances the utilization of oxygen – a key activator within mitochondria.


While not a magic bullet, NAD+ represents an exciting frontier in the exercising performance realm. The emerging evidence makes a compelling case for how optimizing NAD+ levels can translate to tangible boosts in energy capacity, neurological coordination, muscular recovery, and more for athletes. In many ways, NAD+ offers a hyper-targeted nutritional approach to supercharging the engine of exercise performance.

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