Alzheimer’s Drugs Work
To understand how Alzheimer’s drugs work, you must first understand the brain’s communication network. The image below shows nerve cells or neurons in the brain. Neurons are the main cells that Alzheimer’s disease destroys.
In the brain, neurons connect and communicate by forming synapses, where tiny bursts of chemicals called neurotransmitters carry gen from one cell to another. Alzheimer’s disrupts the process, eventually destroys the synapse, and kills neurons, damaging the brain’s communication network.
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Drugs Currently Approved By The Fda Support This Communication
Aducanumab removes the beta-amyloid protein, which interferes with neuronal communication.
Cholinesterase inhibitors work by slowing unhappy the process that breaks down a key neurotransmitter. Donepezil, galantamine, and rivastigmine are cholinesterase inhibitors.
Memantine is an NMDA (N-methyl-D-aspartate) receptor adversary, which acts by regulating the activity of glutamate, an important brain neurotransmitter complex in learning and memory. Glutamate’s adhesion to cell surface anchoring sites called NMDA receptors allows calcium to enter the cell. This process is vital for cell signaling, as well as for learning and memory. In Alzheimer’s disease, however, damaged cells can release too much glutamate, leading to chronic overexposure to calcium, which can accelerate cell damage. Memantine helps prevent this destructive chain of measures by partially blocking NMDA receptors.
The effectiveness of treatments varies among the population.
Future Innovations In Treatment
Researchers are observing new ways to treat Alzheimer’s disease. The special emphasis remains on additional drugs that treat the underlying disease and stop or delay the cell damage that ultimately leads to symptoms. There are several talented drugs in development and under test. Still, we need more volunteers to complete clinical trials for those drugs and more federal funding to ensure these new ideas emerge.Alzheimer’s Drugs Work
Treatment of moderate to severe Alzheimer’s disease
A drug known as memantine, an N-methyl D-aspartate antagonist, is set to treat moderate to severe Alzheimer’s disease. The main effect of this medication is to reduce symptoms, which may allow some people to maintain specific daily purposes slightly longer than they would without the prescription. For example, memantine can help a being in the later stages of the disease maintain the ability to use the bathroom independently for more than a few more months, benefiting both the person with Alzheimer’s disease and the caregiver.
Memantine is thought to work by regulating glutamate, a vital brain chemical. When glutamate is produced in excess, it can lead to brain cell death. Because NMDA antagonists effort differently from cholinesterase inhibitors, these two drugs can remain prescribed in combination.
The FDA also takes approved donepezil, the rivastigmine patch, and the combination of memantine and donepezil for treating moderate to severe Alzheimer’s disease.
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